Phenylethylbarbituric acid.



UNITED STATES PATENT OFFICE.

HEINRICH. HOERLEIN, OF VOHWINKEL,

FARBENFABRIKEN VORM. FRIEDR. CORPORATION OF GERMANY.

NEAR ELBEBFELID, GERMANY, ASSIG-NOR T0 v BAYER & C0., OF ELBERFELD, GERMANY, A

PHENYLETHYLBABIBITURIG ACI'D.

No Drawing.

To all whom it may concern Be it known that I, HEINRICH I-IOERLEIN,

doctor of philosophy, chemist, a citizen of the German Empire, residing at Vohwinkel, near Elberfeld, Germany, have invented new and useful Improvements in Phenyl: et-hylbarbituric Acid, of which the following is a specification.

My invention relates to the manufacture and production of the hitherto unknown phelnylethylbarbituric acid having the for- 11111 a:

which has proved to be a valuable hypnotic;

an average dose being from 1 to a gram.

The process condensing phenyl-ethylmalonic acid ester with urea in the presence of sodium alcoholate i oo-NII Specification of Letters Patent.

for its production consists in.

Patented May '7, 1912.

Application filed September 6, 1911. Serial No. 647,902.

mixture is filtered the alcohol is distilled off in vacuo, water is added to the residue and a precipitate thus obtained is filtered 011'.

- The alkaline filtrate is heated and the heated liquid is neutralized with dilute hydrochloric acid. The phenylethylbarbituric acid precipitates from the cooling liquid.

My new substance crystallizes from water in the shape of white leaflets melting at ITO-172 C. It possesses the property of forming salts with many metals 6. g. the alkali metals, or the calcium, the hydrogen of the NH group being replaced by the metal. It may be either used in the acid or salt form. The sodium salt is a white crystalline powder easily soluble in water.

I claim The herein described phenylethylbarbituric acid of" the formula:

- CH (go-:11

crystallizin from water in the shape of white, lea ets melting at 170172 0.; forming salts with alkali metals and calcium; and being a valuable hypnotic, substantially as described.

In testimony whereof I have hereunto set my hand in the presence of two subscribing witnesses.

HEINRICH HOERLEIN. [1,. s.] \Vitnesses:

ALBERT F. NUFER,

L. NUFER. 

